by Wei Liu | Sep 1, 2021 | Blog
As a gold standard, Sanger sequencing provides 99.99% accuracy and is the most commonly used sequencing method although NGS has dominated in the research field and is routinely used in many clinical labs. However, the limit in sensitivity has restricted the use of...
by Wei Liu | Feb 26, 2021 | Blog
SNPs and Human Diseases SNPs, single nucleotide polymorphism, is the simplest genetic variation and occurs in every 1000 bases in human genomic DNA. Among the 3.5 million SNPs, some lie in intergenic regions (non-coding regions that play regulatory roles) while others...
by Wei Liu | Mar 11, 2021 | Blog, Uncategorized
Bacteria and pathogen identification and methods Microbes or pathogens identification is common for both research (microbial community studies) and clinics (pathogen identification for infectious diseases). In clinical microbiology labs, fast and correct...
by Wei Liu | Mar 26, 2021 | Blog
Parkinson Disease: a common neurodegenerative disorder Parkinson diseases (PD) is the second most common neurodegenerative disorder that usually has a late onset; it affects 1% of the population over age 60 and a total 4million people in the globe. The people with PD...
by Wei Liu | Apr 5, 2021 | Blog
Sanger sequencing data files can be used to measure copy number proportions A couple of months ago, we read the overlapping peaks of both the wildtype and the BRAF V600E mutant traces in the electropherogram of Sanger sequencing from a clinical sample. We wanted to...
by Wei Liu | May 19, 2021 | Blog
Covid-19 and Variants of Concern Since its first occurrence in 2019, COVID-19 has been spreading globally infecting close to 165 million people and having killed more than 3.4 million people as of May19, 2021. The CDC has recommended self-protection measures such as...
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